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"catheter"

Review Article

Ultrasound-guided brachiocephalic and axillary venous cannulation: a narrative review
Kyungwon Lee
J Acute Care Surg 2025;15(3):91-98.   Published online November 30, 2025
DOI: https://doi.org/10.17479/jacs.2025.0023
With the widespread adoption of ultrasound-guided (USG) techniques, the traditional landmark-guided infraclavicular approach for central venous cannulation has declined in use. The subclavian vein offers distinct advantages, and there are circumstances where central venous catheter insertion into the subclavian vein (SCV) is necessary, particularly when access to the internal jugular vein is difficult. When the conventional method is challenging, alternative strategies for SCV cannulation are required. This review examines current concepts and available evidence regarding USG supraclavicular brachiocephalic vein (SC-BCV) and infraclavicular axillary vein (IC-AXV) cannulation as practical alternatives for central venous access. USG SC-BCV cannulation has several advantages, including a shorter distance to the target vein, a more direct catheter trajectory to the superior vena cava, and reduced risks of pneumothorax and arterial puncture. Comparative studies and meta-analyses demonstrate higher first-attempt success rates and lower malposition rates compared with landmark-guided IC-SCV cannulation. USG IC-AXV cannulation is also increasingly recognized as a safe and effective option, particularly useful in patients with tracheostomy, chest wall injuries, or infection risks near conventional sites. Evidence suggests that success rates are comparable to those of internal jugular vein (IJV) cannulation, with fewer infectious complications in selected patients. Both SC-BCV and IC-AXV approaches require proficiency with long-axis imaging and precise needle tracking but can be mastered with training. Accumulating evidence supports USG SC-BCV and IC-AXV cannulation as reliable alternatives to both landmark-guided IC-SCV and USG IJV approaches.
  • 1,146 View
  • 28 Download
Original Articles

Critical care, Infection/Sepsis

Analysis of Risk Factors for Peripherally Inserted Central Venous Catheter-Associated Bloodstream Infection
Sungho Lee, Kwanhoon Park, Kang Yoon Lee, Dongbeen Choi, Ji Young Jang
J Acute Care Surg 2024;14(1):9-15.   Published online March 21, 2024
DOI: https://doi.org/10.17479/jacs.2024.14.1.9
Purpose
Despite guidelines on the prevention of central venous line-associated bloodstream infection, it is left to the clinical judgment of the attending physician to determine the risk of infection and how long a central line should remain in place. This study aimed to identify risk factors for peripherally inserted central venous catheter (PICC)-associated infection.
Methods
This retrospective study included 1,136 patients with a PICC who were hospitalized at the National Health Insurance Service Ilsan Hospital (January 2015 to January 2022). Electronic medical records were reviewed for patients with positive blood cultures. Patients with suspicion of infection at the PICC insertion site or with unclear infection at other sites were defined as having a PICC-associated infection.
Results
Thirty-five patients (3.08%) had a PICC-associated infection. There were significant differences in hypertension (p = 0.026), lung disease (p = 0.001), PICC duration > 14 days, and antibiotic use before PICC insertion (p = 0.016) between no PICC-associated infection, and infection in the bloodstream. Total parenteral nutrition with PICC was not significantly different between groups. Logistic regression analysis identified hypertension, lung disease, PICC duration > 14 days (OR 2.088, 95% CI 1.032-4.224, p = 0.041), and antibiotic use before PICC insertion (OR 0.159, 95% CI 0.049-0.515, p = 0.002) as independent risk factors for PICC-associated infection.
Conclusion
The study suggested that PICCs maintained longer than 14 days is a risk factor for PICC-associated infection. Antibiotic use prior to PICC insertion was observed as a negative factor for PICC-associated infection.
  • 5,596 View
  • 75 Download

Critical care

Purpose
Patients with coronavirus disease 2019 (COVID-19) should be isolated from others to prevent widespread infection. The purpose of this study was to evaluate the feasibility of performing peripherally inserted central catheter (PICC) placement in patients with COVID-19 isolated in the intensive care unit (ICU) of a small volume center hospital.
Methods
This retrospective study included 79 patients who underwent PICC in 2 ICUs. There were 41 patients with COVID-19 who were isolated in an ICU (isolated ICU) and there were 38 patients who required ICU care who did not have COVID-19 (non-isolated ICU). Their medical records including PICC-related complications and clinical variables were compared.
Results
PICC placement was performed to maintain long-term intravenous access for 78% of the COVID-19 group and 52.6% of the non-COVID-19 group (p = 0.017). The mean procedure time (minutes) was 15.2 ± 7.58 in the COVID-19 group and 12.6 ± 6.65 in the non-COVID-19 group (p = 0.109). When PICC tip locations were divided into three groups (optimal, suboptimal, and malpositioned), there was no significant difference between the two groups of patients. PICC-related complications in COVID-19 and non-COVID-19 groups included non-functioning catheter (0% vs. 5.3%, p = 0.137), occurrence of swelling or hematoma around PICC inserted site (2.4% vs. 0%, p = 0.333), and PICC-related infection.
Conclusion
PICC placement for patients with COVID-19 isolated in the ICU of a small volume center hospital was feasible and safe.

Citations

Citations to this article as recorded by  
  • Outcomes of a bedside ultrasound-guided peripherally-inserted central catheter placement across critically-ill older patients
    Kyungwon Lee, Kyoung Won Yoon, Minchang Kang, Donghyoun Lee, Kiyan Heybati
    PLOS One.2026; 21(3): e0336966.     CrossRef
  • Analysis of Risk Factors for Peripherally Inserted Central Venous Catheter-Associated Bloodstream Infection
    Sungho Lee, Kwanhoon Park, Kang Yoon Lee, Dongbeen Choi, Ji Young Jang
    Journal of Acute Care Surgery.2024; 14(1): 9.     CrossRef
  • 4,457 View
  • 47 Download
  • 2 Crossref

Critical care

Bedside Ultrasound-Guided Peripherally Inserted Central Catheter Placement by Critical Care Fellows in Critically Ill Patients: A Feasibility and Safety Study
Jeeyoun Lim, Chi Ryang Chung, Jeong-Am Ryu, Eunmi Gil
J Acute Care Surg 2021;11(1):30-35.   Published online March 24, 2021
DOI: https://doi.org/10.17479/jacs.2021.1.30
Purpose
In the intensive care unit, a peripherally inserted central catheter (PICC) may be an alternative option to standard central venous catheters, particularly in patients with coagulopathies or at high risk of infection. The purpose of this research was to assess the feasibility of bedside ultrasound (US)-guided PICC placement by critical care fellows on intensive care units.

Methods
All bedside US-PICCs inserted by critical care fellows from July 2013 to September 2015 were retrospectively reviewed focusing on the rate of successful insertion, complications of insertion, or during maintenance.

Results
A total of 177 US-guided PICCs were inserted in 163 patients and included in the analysis. The median age was 62 years (IQR 50-70 years) and 104 cases (58.8%) were male. There were 172 cases (90.4%) of PICCs inserted in the upper arm. Anticoagulant therapy was used in 26 patients (14.7%) and 8 patients (5.2%) had severe coagulopathies. The median procedural time was 30 minutes (IQR 19-45 minutes). Insertion success rate was 93.2%, and there were no major complications during insertions except for malposition (12.1%). Catheters remained in place for a total of 3,878 days (median 16 days: IQR 8-31 days). There was only 1 case (0.6%) of catheter-related bloodstream infection, and 2 cases (1.2%) of symptomatic venous thromboembolism.

Conclusion
Bedside US-guided placement of PICCs by critical care fellows is safe and feasible. The success rate of the procedure was “acceptable,” and was not associated with significant risks of infectious and non-infectious complications, even in patients with coagulopathies.

Citations

Citations to this article as recorded by  
  • Analysis of tip malposition and correction of peripherally inserted central catheters under ultrasound-guidance: 5-year outcomes from a single center
    Eunju Jang, Soo Mi Son, Ki-yoon Moon, Seunghoon Lee, Hong Seok Han, Sun Cheol Park, Jang Yong Kim, Sang Seob Yun
    The Journal of Vascular Access.2025; 26(1): 72.     CrossRef
  • Analysis of Risk Factors for Peripherally Inserted Central Venous Catheter-Associated Bloodstream Infection
    Sungho Lee, Kwanhoon Park, Kang Yoon Lee, Dongbeen Choi, Ji Young Jang
    Journal of Acute Care Surgery.2024; 14(1): 9.     CrossRef
  • Development and validation of an updated PICC length prediction formula based on anteroposterior chest radiographs for the ultrasound-guided bedside placement
    Hyoung Nam Lee, Sangjoon Lee, Sung-Joon Park, Youngjong Cho, Hwan Hoon Chung, Robert Jeenchen Chen
    PLOS ONE.2023; 18(11): e0294598.     CrossRef
  • Validation of the PICC length prediction formula based on anteroposterior chest radiographs for bedside ultrasound-guided placement
    Youngjong Cho, Sangjoon Lee, Sung-Joon Park, Hyoung Nam Lee, Hwan Hoon Chung, Robert Jeenchen Chen
    PLOS ONE.2022; 17(11): e0277526.     CrossRef
  • Feasibility of Peripherally Inserted Central Catheter Placement in COVID-19 Patients Isolated in the Intensive Care Unit of a Small Volume Center (291-Bed Hospital)
    Min Chang Kang, Kyungwon Lee
    Journal of Acute Care Surgery.2022; 12(3): 125.     CrossRef
  • 8,571 View
  • 119 Download
  • 5 Crossref

Critical care

Clinical Characteristics of Peripherally Inserted Central Catheter in Critically Ill Patients
Hyoung-Joo Kim, Chang-Yeon Jung, Jung-Min Bae
J Acute Care Surg 2019;9(1):18-24.   Published online April 30, 2019
DOI: https://doi.org/10.17479/jacs.2019.9.1.18
Purpose:

Ensuring the stability of central venous catheter placement for treating patients hospitalized in an intensive care unit is very important. Although PICC requires an ultrasound and fluoroscopy machine, it is difficult to use a fluoroscopy machine for PICC insertion in the intensive care unit. This study analyzed the cases of the insertion of a PICC under ultrasonic guidance at the bedsides in the intensive care unit to determine the usefulness of PICC in the intensive care unit.

Methods:

A retrospective study was conducted on patients hospitalized in the surgical intensive care unit and received PICC using ultrasonography at their bedsides from October 2015 to January 2018.

Results:

One hundred and twenty patients were collected. The number of successful PICCs stood at 105 patients, which was equal to 87.5%. Among them, 65 and 55 cases had left and right insertion, respectively; the corresponding success rate was 81.8%, and 92.3%. No statistically significant difference in success rates was observed between the left and right, as well as in the success rates depending on the presence of shock, sepsis, acute kidney injury, and mechanical ventilation. In the failed 15 cases, seven cases were due to the course of the procedure and eight cases were confirmed have been malpositioned after insertion.

Conclusion:

PICC at the bedside in an intensive care unit is a safe method for central venous catheterization without severe complications and death. The insertion sites, left or right, are equally acceptable. Further study of the cases of malposition will be necessary.

Citations

Citations to this article as recorded by  
  • Anatomical Structures to Be Concerned With During Peripherally Inserted Central Catheter Procedures
    Dasom Kim, Jin Woo Park, Sung Bum Cho, Im Joo Rhyu
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Peripherally inserted central catheter procedure at the bedside by a nephrologist is safe and successful
    Seong Cho
    Kidney Research and Clinical Practice.2021; 40(1): 153.     CrossRef
  • 9,712 View
  • 287 Download
  • 2 Crossref

Critical care

Central Line-Associated Bloodstream Infection Prevention by Central Venous Catheter Management Staff in the Surgical Intensive Care Unit
Jin-Uk Choi, Nak-Jun Choi, Suk-Kyung Hong, Tae-Hyun Kim, Min Ae Keum, Se Ra Kim, Sun Ju Lee, Sung-Dae Shin
J Acute Care Surg 2018;8(2):65-70.   Published online October 30, 2018
DOI: https://doi.org/10.17479/jacs.2018.8.2.65
Purpose:

Patients in the intensive care unit (ICU) are more susceptible to nosocomial infections, including central line-associated bloodstream infection (CLABSI), surgical site infection, urinary tract infection or ventilator-associated pneumonia. This study is a comparative analysis of how central venous catheter (CVC) management staff affects CLABSI.

Methods:

We performed a two-phase review of all patients transferred to the surgical ICU (SICU) from January 2013 to June 2014. CVC management staff was introduced in October 2013. Electronic medical records provided the data for a comparative analysis of incidence rates and risks of CLABSI, as well as the subjects’ general characteristics.

Results:

This study included 248 patients before the introduction of a CVC management staff member and 196 patients after the introduction. General patient characteristics before and after the CVC management staff was in place did not differ significantly. The CLABSI rate decreased by 4.61 cases/1,000 device days after the introduction (6.26 vs. 1.65; odds ratio, 4.47; 95% confidence interval, 1.39∼14.37; p=0.009). However, the mortality rate and length of ICU stay did not change after CVC management staff was in place (12.9% vs. 10.7%, p=0.480; 16.00±24.89 vs. 15.87±18.80, p=0.954; respectively).

Conclusion:

In this study, the introduction of CVC management staff effectively reduced CLABSI rates in current ICU system.

  • 6,292 View
  • 101 Download

Procedure

Peripherally Inserted Central Catheter in Trauma Patients: Early Experience at a Single Institute
Gil Hwan Kim, Sang Bong Lee, Jae Hun Kim, Chan Kyu Lee
J Acute Care Surg 2017;7(2):69-74.   Published online October 30, 2017
DOI: https://doi.org/10.17479/jacs.2017.7.2.69
Purpose:

A peripherally inserted central catheter (PICC) provides effective, reliable intravenous access in patients who require long term therapy such as intravenous antibiotics, total parenteral nutrition, transfusion or inotropic agents. This retrospective study evaluated the usefulness of PICC in trauma patients by examining patient characteristics and common complications, including PICC related bloodstream infection.

Methods:

We reviewed the trauma patients who underwent PICC at Pusan National University Hospital Trauma Center from January 2016 to February 2017.

Results:

From January 2016 to February 2017, 32 patients underwent PICC. Total catheter insertion days were 875 days, and the average catheter indwelling time was 27.3±25.02 days. The most common indication for PICC was total parenteral nutrition (n=20, 62.5%), while the remainder was to ensure a long-term fluid administration route (n=12, 37.5%). Catheter related complications included infection (n=3, 9.4%; 3.42 per 1,000 catheter-days), catheter tip malposition (n=2, 6.3%), catheter dislodgement (n=1, 3.1%), insertion site leakage (n=1, 3.1%) and arm swelling (n=1, 3.1%). No statistically significant differences were found between those who developed bloodstream infection and those who did not.

Conclusion:

If the PICC is performed by correcting adjustable factors that increase the risk of infection, effective and reliable intravenous access can be maintained in patients who require long-term therapy without bleeding, pneumothorax, or other complications of central venous catheter insertion.

  • 7,603 View
  • 52 Download
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