Traditionally stress hyperglycemia was considered to be a adaptive response, with raised blood glucose providing a fuel for the brain, skeletal muscle, heart and other vital organs. In 2001, intensive insuline therapy (IIT) that demonstrated a survival benefit in surgical critical care led to clinicians to control glucose within tight range (＜110 mg/dl). However, randomized controlled studies including NICE-SUGAR study have shown IIT was no survival benefit compared with conventional therapy (CT). Now, controlling blood glucose within 140∼180 mg/dl in sepsis patients is accepted as reasonable range because IIT was related with frequent hypoglycemic events and no survival benefit compared with CT. (J Surg Crit Care 2013;3:18-21)
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