Intestinal fistula or enterocutaneous fistula is an abnormal tract between skin and gastrointestinal tract, and one of the challenging problem to manage. If not adequately managed, a patient with fistula can develop severe morbidity and mortality such as fluid and electrolyte imbalances, wound infection, and sepsis. Here we report a case of enterocutaneous fistula developed as a postoperative complication of gastrointestinal stromal tumor excision, and then review the management of a patient with enterocutaneous fistula. (J Acute Care Surg 2013;3:69-72)