Management of Adult Blunt Renal Injury: A 10-Year Retrospective Review at a Single Institution

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J Acute Care Surg. 2023;13(1):21-26

Publication date (electronic) : 2023 March 21

doi : https://doi.org/10.17479/jacs.2023.13.1.21

Jin Soo Kim^a, Ki Hoon Kim^a,, Se Hun Kim^b

^aDepartment of Surgery, Inje University Haeundae Paik Hospital, Busan, Korea

^bDepartment of Anesthesiology, Inje University Haeundae Paik Hospital, Busan, Korea

^*Corresponding Author: Ki Hoon Kim, Department of Surgery, Inje University, Haeundae Paik Hospital, 48108, 1435, Jwa-dong, Haeundae-gu, Busan, Korea, E-mail: medhun@hanmail.net

Received 2023 January 28; Revised 2023 February 20; Accepted 2023 March 7.

Abstract

Introduction

Anatomically, the kidneys are well-protected by strong lumbar muscles, vertebrae, ribs, and abdominal viscera on the anterior side. However, these genitourinary organs are most often injured as a result of blunt trauma [1]. Renal injury occurs in up to 5% of all trauma cases and the kidney is the 3rd most wounded solid abdominal organ [2–5]. The ultimate goal of kidney-injury treatment is to save the patient’s life by controlling bleeding, preserving nephron function (as much as possible), and minimizing the risk of related complications. In the past, the common practice for achieving these goals was surgery. Recently, nonoperative management has been proposed as a standard treatment method for patients with low-grade blunt renal injury [4–6]. This shift was driven by the accrued knowledge over the last 3 decades on the safety and outcome of nonoperative management, with advances in imaging and embolization techniques, and in minimally invasive treatment techniques such as ureteral stenting [7–10]. In addition, the treatment of patients with high-grade renal injury has also been shifting from surgery to nonsurgical treatments [6–8].

The guidelines of the World Society of Emergency Surgery (WSES) and the American Association for the Surgery of Trauma (AAST) recommend nonoperative management, which may include angioembolization, if vital signs are stable, regardless of the AAST Kidney injury scale [3]. While surgical treatment is recommended for patients who are hemodynamically unstable and not responsive to fluid resuscitation, the WSES-AAST guidelines suggest that nonoperative management should always be considered as the first option whenever possible [3].

Compared with trauma centers (with specialized teams and equipment to handle serious trauma), non-trauma centers have limitations in following the WSES guidelines in the treatment of renal injury patients due to the lack of resources and expertise.

The objective of this study was to review cases of blunt renal injury at a non-trauma center, analyze the clinical features and outcomes of patients, and consider the care of high-grade blunt renal injury patients.

Materials and Methods

This retrospective study was approved by the institutional review board of Haeundae Paik Hospital (no.: HPIRB 2021-10-009). The clinical data of patients who presented in the Emergency Department (ED) with blunt abdominal injury between March 2010 and December 2020 were identified from electronic patient records. The inclusion criteria were patients aged > 18 years who were admitted to the Emergency Department with blunt abdominal trauma. Patients excluded from the study: ≤ 18 years, suspected renal trauma but without computed tomography (CT)-verification, died in the Emergency Department, or had renal trauma (ureter or bladder).

Data collected included age, sex, mechanism of injury, renal injury grade according to the AAST Organ injury scale, injury severity score (ISS), heart rate, systolic blood pressure, laboratory data including hemoglobin levels (particularly the lowest level recorded during the first 24 hours), other associated injuries, transfusion within two days of hospitalization, treatment options, length of stay (LOS) in the intensive care unit, LOS in the hospital, and mortality. All patients underwent contrast-enhanced CT at the time of ER admission. Renal injury was diagnosed using CT and was classified according to the AAST Kidney injury scale. Patients with renal injury were grouped as low-grade injury (AAST Grade I and II), or high-grade injury (AAST Grade III to V) based on the 2018 AAST Organ injury scale [11].

The Kolmogorov-¬Smirnov test was performed on the data to verify the assumption of normality. Categorical data were reported as numbers and percentages, whereas continuous data were reported as the median and interquartile range. Categorical variables were compared using the Chi-square or Fisher’s exact tests, whereas continuous variables were compared using the Mann-Whitney U test. All statistical analyses were performed using MedCalc software (MedCalc Software Ltd., Ostend, Belgium). Differences were considered significant if the two-tailed p value was < 0.05.

Results

A total of 92 trauma patients with kidney injury presented at the ER of Haeundae Paik Hospital between March 2010 and February 2020. Based upon the study inclusion criteria, 24 patients were excluded, and the data of the remaining 68 patients were analyzed.

The median age of the patients was 52 years (interquartile range 33–61 years), and 75.0% of the patients were male (Table 1). Fall injuries were the most common cause of blunt kidney trauma (48.5%) followed by motor vehicle accidents (20.6%). The grade of renal injury according to the AAST Kidney injury scale and mechanism of injury are illustrated in Figure 1. There were 98.5% (n = 67) of the patients who were treated nonoperatively including embolization (n = 8), and ureteral stenting (n = 1; Table 1). Nephrectomy was performed in one patient, and the overall treatment mortality rate was 2.9% (n = 2; Table 1). One patient died of aggravated cerebral edema after surgery for traumatic subdural hemorrhage, and one patient died of sepsis related to intraperitoneal organ surgery.

Table 1

Demographics of patients with blunt renal trauma (age > 18).

Figure 1

Distribution of renal injuries by mechanism and American Association for the Surgery of Trauma scale.

In this study, 16 patients (23.5%) had isolated renal trauma, and injuries in the chest region (n = 39, 57.4%) which were most associated with renal trauma (Table 2).

Table 2

Injures of organs related to renal injury (age >18).

Forty-five patients (66.2%) were high-grade renal injury patients. The numbers of patients with high-grade injury, tachycardia, hypotension, presence of transfusion, associated injury with renal injury, LOS in the intensive care unit, and overall mortality were higher than the number of patients with low-grade renal injury, but these differences were not statistically significant (Table 3). There was no statistically significant difference in nonoperative treatment including embolization, between the patients with high-grade injury (n = 44, 97.8%) and the patients with low-grade injury (n = 23, 100%; p = 0.511; Table 3). Nonoperative treatment was performed in all patients with low-grade renal injury, and eight cases of embolization, one case of ureteral stenting, and one case of nephrectomy were performed in patients with high-grade renal injury (Figure 2).

Table 3

Differences between low-grade and high-grade blunt renal injury.

Figure 2

Management of blunt renal trauma according to injury severity.

Discussion

Non-surgical treatment is recommended as the treatment of choice for hemodynamically stable or stable high-grade blunt renal injury [3]. In this study, 66.2% (n = 45) of blunt renal injury patients (n = 68) had high-grade injury. Nonoperative management including embolization and ureteral stenting was successful in 97.8% (n = 44) of the high-grade renal injury group.

During the initial resuscitation of trauma patients, intra-abdominal organ bleeding can be diagnosed rapidly using sonography to perform a focused assessment of the trauma [12–14]; however, in the case of kidney injury, early diagnosis is difficult because of the anatomical location of the kidney. Advances in CT imaging and embolization have enabled a high success rate detecting the location and nonsurgical treatment of bleeding in cases of damage to solid abdominal organs such as the liver and spleen [15–17]. The accumulation of skill in nonsurgical treatment of solid organs has made it possible to change the treatment paradigm from surgical (performing a nephrectomy) to conservative treatment of renal injury.

The kidney is only held in position by the renal pelvis and vascular pedicle, therefore, it is particularly vulnerable to decelerating injuries, such as falls, and motor vehicle collisions [3]. Studies have shown that falls and car accidents are the most common causes of renal injury [2,5,18,19]. In a retrospective study over 15 years, using data from the Japan Trauma Data Bank, patients with blunt renal trauma were identified (n = 3,550) and falls accounted for 34% of injuries, and car accidents accounted for 15.7% [18]. Another retrospective study over 8 years using the Taiwan National Trauma Bank (n = 10,096) reported that the most common mechanisms of renal injury were motor vehicle accidents (49.4%) and falls (27.4%) [19]. Motor vehicle accidents have been reported to be the most common cause of high-grade renal injury [2,5]. In cases of renal injury caused by high-energy mechanisms such as falls or traffic accidents, the incidence of high-grade renal injury is reported to be between 47.4% and 76% [1,2,18,20]. The mechanism of injury in the present study showed that 32 patients (48.5%) had experienced a fall, and 20.6% had been in a motor vehicle accident. Falls accounted for 51.1% and motor vehicle accidents for 13.3% cases of high-grade renal injury. The incidence rate of high-grade renal injury was 66.2%, which was similar to that reported by other institutions.

The high-energy impact that results in renal injury can also damage adjacent structures including the liver, spleen, and other abdominal organs, resulting in multiple injuries. Several studies have reported that patients with traumatic kidney injury often have concomitant injuries to other organs [1,4,20–23]. In a Danish retrospective study, 58% (n = 107) of patients had injuries to other organs [20]. In an American study of 206 adult patients with Grade 4 or 5 blunt renal injury; concomitant injuries were observed in 94.2% of patients who underwent immediate surgery and 74.7% of those who received nonoperative management [21]. A study conducted in South Africa reported that associated organ injury occurred in 68.5% of cases, and the frequency of intra-abdominal organ injuries due to blunt trauma was highest in the liver (44.4%), followed by the spleen (31.5%) [4]. In a retrospective study of the Japan Trauma Bank, 85.7% of patients with blunt renal injury had multiple injuries, with associated intra-abdominal organ injury in the liver (27.3%) and spleen (18.5%) [18]. Our data showed that concomitant injuries occurred in 53 of the 68 patients (76.5%) and 35 of the 45 patients (77.8%) with high-grade blunt renal injury. Associated intra-abdominal organ injuries occurred in 16.2% in the liver, 14.7% in the adrenal glands, and 10.3% in the spleen.

Advances in radiological techniques and selective treatment with interventional radiology have reduced the need for surgical treatment, even for high-grade renal injury. A study by Khoschnau et al [2], reported that among 152 patients hospitalized for blunt renal injury, most (93%) patients were treated conservatively including those with high-grade renal injury. Salem et al [4] reported conservative treatment outcomes in 80.8% of patients with high-grade blunt renal injury, and ≥ 78.8% of all patients in their five-year trauma management experience report. The authors suggested that, even with high-grade renal injury, nonsurgical treatment is safe and was associated with good outcomes [4]. The results of the AAST Genitourinary Trauma Study reported by Keihani et al [22] in 2018, showed that although penetrating injuries were often treated with nephrectomy, more than 90% of patients with blunt trauma can be treated conservatively. Nonoperative management is recommended for patients with hemodynamically stable or stabilized severe lesions without other reasons for surgical exploration [3]. However, in a survey of practice patterns for the treatment of high-grade renal trauma, of 253 practitioners, 95% of respondents agreed to preserve the kidney, but 50% of practitioners actually performed a nephrectomy for acute renal trauma management such as in case of severe renal bleeding within the first 4 hours of arrival or an exploratory laparotomy for other abdominal injuries with renal bleeding [23]. These results are consistent with those of a multicenter AAST study that showed that a nephrectomy was the most common intervention for bleeding in advanced trauma in 13% of cases, whereas angioembolization was performed in only 6% of patients [22]. Angioembolization of renal injuries is associated with a high success rate, even in patients with high-grade injuries [3,24]. In the present study, nonoperative management was performed in 98.5% of all patients, and was successful in 97.8% of patients with high-grade renal injuries.

This study has several limitations. Firstly, the data were retrospectively collated from medical records, and no randomization technique was applied. Secondly, this study included only a small number of patients who were admitted to a single institution. The small sample size may have reduced statistical power and thus the significance of the results obtained. Selecting a treatment method for blunt kidney injury can differ depending on the attending physician who makes the treatment decision, which results in variations in management. To resolve these limitations, a prospective, multicenter, large-scale study is required.

In conclusion, even with a high-grade renal injury, most patients with a traumatic renal injury can be managed with nonoperative treatment including angioembolization, and can have a good prognosis. The decision-making process for treatment options should be individualized for each patient, but nonoperative management should be considered whenever possible.

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